Development of an EEG-fMRI-TMS system for optimal alpha phase synchronized activation of anterior cingulate cortex

James McIntosh, Josef Faller, GT Saber, J Doose, Yida Lin, H Moss, Robin Goldman, MS George, Paul Sajda, Truman R. Brown

Rostral anterior cingulate cortex (rACC) is an integral part of the depression network.
rACC activity may predict antidepressant effect.
Stimulation of left dorsolateral prefrontal cortex (lDLPFC) causes a reciprocal change in certain parts of the ACC.
We hypothesise that improvements in the method of transcranial magnetic stimulation (TMS) delivery to the lDLPFC may produce an antidepressant effect.