An EEG-fMRI-TMS system for investigating BOLD response to alpha phase-locked TMS

Transcranial magnetic stimulation (TMS) triggered in synchrony with brain rhythms may potentially lead to improved performance in TMS treatment for clinical populations. We developed a system that can process and predict EEG rhythms in real time and trigger TMS at a designated phase. We applied the MRI-compatible system to 11 healthy subjects and showed that it was able to mark the target phase with satisfactory accuracy. This demonstrates the feasibility of synchronized TMS pulsing and will be developed further for application in a clinical population.

Accepted 21 June 2018
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