Level of TMS-evoked activation in anterior cingulate cortex depends on timing of TMS delivery relative to frontal alpha phase

G.T. Saber, James McIntosh, J. Doose, Josef Faller, Yida Lin, H. Moss, Robin Goldman, MS George, Paul Sajda, Truman R. Brown

To test whether the level of activation of the anterior cingulate cortex (ACC) following a TMS pulse delivered to the dorsolateral prefrontal cortex depends on precise timing of its delivery relative to an individual’s alpha rhythm, we developed an integrated EEG-fMRI-TMS instrument capable of acquiring simultaneous EEG-fMRI while delivering TMS pulses in the scanner. We found a statistically significant effect of BOLD signal change in ACC dependent on individual subject frontal alpha phase just prior to TMS delivery. Specifically, TMS-evoked BOLD response in the ACC increased when TMS pulse was synchronized to the rising slope of the frontal alpha oscillation.

Accepted 2 February 2018
Download Now

Latest News & Links

See All News